Articles in SCI Journals

    • Malliou F, Andreadou I, Gonzalez FJ, LAZOU A, … Konstandi M (2018). The olive constituent oleuropein, as a PPARα agonist, reduces markedly serum triglycerides. J Nutr Biochem. 59:17-28
    • Feidantsis K, Mellidis K, Galatou E, Sinakos Z, LAZOU A (2018). Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy. Nutr Metab Cardiovasc Dis. 28(9):952-961
    • Andreadou I, Iliodromitis E, LAZOU A, Görbe A, Giricz Z, Schulz R, Ferdinandy P (2017) Effect of hypercholesterolaemia on myocardial function, ischaemia–reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. Br J Pharmacol 174: 1555-1569.
    • Ravingerova, T; Farkasova, V; Griecsova, L; Murarikova, M; Lonek, L; Neckar, J; Kolar, F; Lazou, A; Zohdi, V; (2017) ,Cardioprotection of the ischemic myocardium induced by preconditioning in the distant organ: the role of peroxisome proliferator-activated receptors,ACTA PHYSIOLOGICA,221:22-24
    • Ravingerová T, Farkašová V, Griecsová L, Muráriková M, Carnická S, Lonek L, Ferko M, Slezak J, Zálešák M, Adameova A, Khandelwal VKM, LAZOU A, Kolar F. (2017). Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans? Can J Physiol Pharmacology 95: 1204-1212.
    • Slezak, Jan; Kura, Branislav; Babal, Pavel; Barancik, Miroslav; Ferko, Miroslav; Frimmel, Karel; Kalocayova, Barbora; Kukreja, Rakesh C; LAZOU, Antigone; Mezesova, Lucia;Okruhlicova L, Ravingerova T, Singal PK, Szeiffova Bacova B, Viczenczova C, Vrbjar N, Tribulova N. (2017). Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury. Can J Physiol Pharmacol: 95,10,1190-1203
    • Egea J et al (2017) European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (2017). Redox Biology 13: 94-162
    • E Barlaka, E Galatou, K Mellidis, T Ravingerova, A Lazou (2016). Role of Pleiotropic Properties of Peroxisome Proliferator‐Activated Receptors in the Heart: Focus on the Nonmetabolic Effects in Cardiac Protection. Cardiovasc Ther 34: 37-48.
    • Ravingerova, T; Farkasova, V; Griecsova, L; Carnicka, S; Murarikova, M; Barlaka, E; Kolar, F; Bartekova, M; Lonek, L; Slezak, J; LAZOU, A (2016).”Remote Preconditioning as a Novel”” Conditioning”” Approach to Repair the Broken Heart: Potential Mechanisms and Clinical Applications”,Physiological Research,65,,S55.
    • Theofanis Vavilis, Nikoleta Delivanoglou, Eleni Aggelidou, Eleni Stamoula, Kyriakos Mellidis, Aikaterini Kaidoglou, Angeliki Cheva, Chryssa Pourzitaki, Katerina Chatzimeletiou, Antigone Lazou, Maria Albani, Aristeidis Kritis (2015). Oxygen–Glucose Deprivation (OGD) Modulates the Unfolded Protein Response (UPR) and Inflicts Autophagy in a PC12 Hypoxia Cell Line Model. Cell Mol Neurobiol
    • Stamoula E, Vavilis T, Aggelidou E, Kaidoglou A, Cheva A, Mellidis K, LAZOU A, Haitoglou C, Albani M, Kritis A (2015). Low Dose Administration of Glutamate Triggers a Non-Apoptotic, Autophagic Response in PC12 Cells. Cell Physiol Biochem. 2015;37(5):1750-8.
    • Barlaka E, Görbe A, Pálóczi J, Gaspar R, Ferdinandy P, LAZOU A (2015). Activation of PPARβ/δ protects cardiac myocytes from oxidative stress-induced apoptosis by suppressing generation of reactive oxygen/nitrogen species and expression of matrix metalloproteinases. Pharmacol Res, 95-96: 102-110.
    • Ravingerová T, Ledvényiová-Farkašová V, Ferko M, Barteková M, Pecháňová O, Adameová A, Kolář F, LAZOU A (2015). Pleiotropic preconditioning-like cardioprotective effects of hypolipidemic drugs in acute ischemia/reperfusion in normal and hypertensive rats. Can J Physiol Pharmacol 93: 495-503.
    • Galatou E, Kelly T, LAZOU A (2014). The PPARβ/δ agonist GW0742 modulates signaling pathways associated with cardiac myocyte growth via a non-genomic redox mechanism. Mol Cell Biochem 395: 145-154
    • Mellidis K, Ordodi V, Galatou E, Săndesc D, Bubenek S, Duicu O, Muntean D, LAZOU A (2014). Activation of prosurvival signaling pathways during the memory phase of volatile anesthetic preconditioning in human myocardium: a pilot study. Mol Cell Biochem 388:195-201
    • Ravingerova T, Carnicka S, Ledvenyiova V, Barlaka E, Galatou E, Chytilova A, Mandikova P, Nemcekova M, Adameova A, Kolar F, LAZOU A. (2013). Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart. Physiol Res 62 Suppl 1:S151-63
    • Barlaka E, Ledvenyiova V, Galatou E, Ferko M, Čarnická S, Ravingerová T, LAZOU A (2013). “Delayed” cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-alpha activation in rat hearts subjected to global ischaemia/reperfusion. Can J Physiol Pharmacol 91:608-616
    • Feidantsis K., Antonopoulou E., LAZOU A., Portner HO, Michaelidis B. (2013). Seasonal variations of cellular stress response of the gilthead sea bream (Sparus aurata). J Comp Physiol B 183: 625-639
    • Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis M, Lazou A, Pappa A. (2013). Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms. J Nutr Biochem 24: 586-594
    • Voucharas C, Tagarakis G, LAZOU A, Triposkiadis F, Tsilimingas N. (2012). Experimental cardiac hypertrophy induced by oral administration of mineralocorticoid and saline in rats. Angiology 63:416-419.
    • Feidantsis K, Pörtner HO, Markou T, LAZOU A, Michaelidis B. (2012). Involvement of p38 MAPK in the Induction of Hsp70 During Acute Thermal Stress in Red Blood Cells of the Gilthead Sea Bream, Sparus aurata. J Exper Zool Part A: Ecological Genetics and Physiology 317:303-310.
    • Ravingerová T, Čarnická S, Nemčeková M, Ledvényiová V, Adameová A, Kelly T, Barlaka E, Galatou E, Khandelwal VKM, LAZOU A. (2012). PPAR-αlpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: Involvement of PI3K-Akt. Can J Physiol Pharmacol 90:1135-1144.
    • Ravingerová T, Adameová A, Čarnická S, Nemčeková M, Kelly T, Matejiková J, Galatou E, Barlaka E, LAZOU A (2011). The role of PPAR in myocardial response to ischemia in normal and diseased heart. Gen Physiol Biophys 30(4): 329-341
    • Voucharas C, LAZOU A, Triposkiadis F, Tsilimingas N (2011). At a distance preconditioning in normal and hypertrophic rat hearts. J Cardiothorac Surg 6:34
    • Markou T, Barlaka E, Bartucci M, LAZOU A (2011). Signal transduction pathways through cytoprotective, apoptotic and hypertrophic stimuli: a comparative study in adult cardiac myocytes.Cell Biochem Funct 29: 442-451
    • Markou T, Makridou Z, Galatou E, LAZOU A (2011). Multiple signalling pathways underlie the cardioprotective effect of levosimendan in cardiac myocytes. Eur J Pharmacol 667: 298-305
    • Ravingerová T, Adameová A, Matejíková J, Kelly T, Nemčeková M, Kucharská J, Pecháňová O, LAZOU A (2010). Subcellular Mechanisms Of Adaptation In The Diabetic Myocardium: Relevance To Ischemic Preconditioning In The Non-Diseased Heart. Exp Clin Cardiol 15 (4): 68-76
    • LAZOU A, Markou T. (2010). Msk1. UCSD-Nature Molecule Pages (2010). doi: 10.1038/mp.a001562.01
    • Iordanidou A, Hadzopoulou-Cladaras M, LAZOU A (2010). Non-genomic effects of thyroid hormone in adult cardiac myocytes: relevance to gene expression and cell growth. Mol Cell Biochem 340: 291-3
    • Ravingerova T, Adameova A, Kelly T, Antonopoulou E, Pancza D, Ondrejčakova M, Khandelwal VKM, Čarnicka S, LAZOU A (2009). Changes in PPAR gene expression and myocardial tolerance to ischaemia: Relevance to pleiotropic effects of statins. Can J Physiol Pharmacol 87: 1028-1036
    • Markou T, Dowling A, Kelly T, Cieslak D, LAZOU A (2009). Regulation of Bcl-2 phosphorylation in response to oxidative stress in cardiac myocytes. Free Radic Res 43:809-816
    • Michaelidis Β, Hatzikamari Μ, Antoniou V, Anestis A, LAZOU A (2009) Stress activated protein kinases, JNKs and p38 MAPK, are differentially activated in ganglia and heart of land snail Helix lucorum (L.) during seasonal hibernation and arousal. Comp. Biochem Physiol A 153: 149-153
    • Markou T, Cieslak D, Gaitanaki C, LAZOU A (2009). Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phelylephrine- induced cardiac myocyte hypertrophy. Mol Cell Biochem 322: 103-112
    • Feidantsis K, Portner HO, LAZOU A, Kostoglou B, Michaelidis (2009). Metabolic and molecular stress responses of marine fish Sparus aurata during long term exposure to increasing temperature. A correlation with vertical distribution. Mar Biol 156: 797:809
    • Anestis A, Portner HO, LAZOU A, Michaelidis B (2008) Metabolic and molecular stress responses of sublittoral bearded horse mussel Modiolus barbatus to warming sea water. Implications for vertical zonation. J Exp Biol 211: 2889-2898.
    • Cieslak D, LAZOU A (2007). Regulation of BAD protein by PKA, PKCδ and phosphatases in adult cardiac myocytes subjected to oxidative stress. Mol Cells: 24:221-231.
    • Iliodromitis EK, LAZOU A, Kremastinos DTh (2007). Ischemic preconditioning: protection against myocardial necrosis and apoptosis. Vasc Risk Health Manag 3: 629-637
    • Anestis A, LAZOU A, Portner HO, Michaelidis B (2007). Behavioural, metabolic and molecular stress responses of marine bivalve Mytilus galloprovinciallis during long-term acclimation at increasing ambient temperature. Am J Physiol. 293: R911-921
    • LAZOU A, Markou T, Zioga M, Vasara E, Efstathiou A, Gaitanaki C (2006). Dopamine mimics the cardioprotective effect of ischemic preconditioning via activation of α1 adrenoceptors in rat heart. Physiological research. 55: 1-8.
    • Iliodromitis E, Gaitanaki C, LAZOU A, Aggeli I-K, Gizas V, Bofilis E, Zoga A, Beis I, Kremastinos D (2006). Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning in rabbits. Basic Res Cardiol 101: 327-335.
    • LAZOU A, Iliodromitis EK, Cieslak D, Voskarides K, Mousikos S , Bofilis E, Kremastinos DT (2006). Ischemic but not mechanical preconditioning attenuates ischemia/reperfusion induced myocardial apoptosis in anaesthetized rabbits: the role of Bcl-2 family proteins and ERK1/2. Apoptosis 11:2197-2204
    • Bitzikas G, Papakonstantinou C, LAZOU A, Bougioukas G, Toumpouras M, Tripsianis G, Spanos P (2005). The supportive value of pre-bypass L-Glutamate loading in patients undergoing coronary artery bypass grafting. J Cardiovasc Surg 46: 551-7.
    • Markou T, Hadzopoulou-Cladaras M and LAZOU A (2004). Phenylephrine induces activation of CREB in adult rat cardiac myocytes through the MSK1 and PKA signaling pathways. J Mol Cell Cardiol 37: 1001-1011
    • Markou T., Vassort G. and LAZOU A. (2003). Regulation of MAPK pathways in response to purinergic stimulation in adult rat cardiac myocytes. Molecular and Cellular Biochemistry 242: 163-171.
    • Vasara E., Katharou I. and LAZOU A. (2003). Myocardial adenosine does not correlate with the protection mediated by ischaemic or pharmacological preconditioning in rat heart. Clinical and Experimental Pharmacology and Physiology 230: 350-356.
    • Aggeli I.-K.S., Gaitanaki C., LAZOU A. and Beis I. (2002). Hyperosmotic and thermal stresses activate p38-MAPK in the perfused amphibian heart. Journal of Experimental Biology 205: 443-454.
    • LAZOU A., Gaitanaki C., Vaxevanellis S. and Pehtelidou A. (2002). Identification of α1-adrenergic receptors and their involvement in phosphoinositide hydrolysis in the frog heart. Journal of Experimental Zoology 293: 99-105.
    • Markou T. and LAZOU A. (2002). Phosphorylation and activation of mitogen- and stress- activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase. Biochemical Journal 365: 757-763.
    • Aggeli I.-K.S., Gaitanaki C., LAZOU A. and Beis I. (2002). α1- and β-adrenoceptor stimulation differentially activate p38-MAPK and atrial natriuretic peptide production in the perfused amphibian heart. Journal of Experimental Biology 205: 2387-2397.
    • Iliodromitis E.K., Gaitanaki C., LAZOU A., Bofilis E., Karavolias G.K., Beis I. and Kremastinos D.Th. (2002). Dissociation of stress-activated protein kinase (p38-MAPK and JNKs) phosphorylation from the protective effect of preconditioning in vivo. Journal of Molecular and Cellular Cardiology 34: 1019-1028.
    • Tsouka V., Markou T. and LAZOU A. (2002). Differential effect of ischemic and pharmacological preconditioning on PKC isoform translocation in adult rat cardiomyocytes. Cellular Physiology and Biochemistry 12: 315-324
    • Vasara E., Seraskeris S. and LAZOU A. (2002). Activation of α1-adrenoceptors is not essential for the mediation of ischaemic preconditioning in rat heart. Clinical and Experimental Pharmacology and Physiology 29:11-17.
    • Seraskeris S. and LAZOU A. (2002). α1-adrenergic stimulation mediates Ca2+-dependent inositol phosphate formation through the α1B-like adrenoceptor subtype in adult rat cardiac myocytes. Journal of Cellular Biochemistry 84:201-210
    • Efstathiou A., Seraskeris S., Papakonstantinou C., Aidonopoulos A. and LAZOU A. (2001). Differential effect of preconditioning on post-ischaemic myocardial performance in the absence of substantial infarction and in extensively infarcted rat hearts. European Journal of Cardiothoracic Surgery 19: 493-499.
    • Aggeli I.-K., Gaitanaki C., LAZOU A. and Beis I. (2001). Activation of multiple MAPK pathways (ERKs, JNKs, p38-MAPK) by diverse stimuli in the amphibian heart. Molecular and Cellular Biochemistry 221: 63-69.
    • Seraskeris S., Gaitanaki C. and LAZOU A. (2001). α1D-Adrenoceptors do not contribute to phosphoinositide hydrolysis in adult rat cardiac myocytes.Archives of Biochemistry and Biophysics 392:117-122.
    • Aggeli I.-K.S., Gaitanaki C., LAZOU A. and Beis I. (2001). Stimulation of multiple MAPK pathways by mechanical overload in the perfused amphibian heart.American Journal of Physiology 281: R1689-R1698
    • LAZOU A., Seraskeris S., Tsiona V. and Drossos G. (2000). Oxidative status and anti-oxidant enzyme activity during calcium paradox in the rat isolated heart.Clinical and Experimental Pharmacology and Physiology 27:160-166
    • LAZOU A., Sugden P.H. and Clerk A. (1998). Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochemical Journal 332: 459-465
    • Drossos G., LAZOU A., Panagopoulos P. and Westaby S. (1995). Deferoxamine cardioplegia reduces superoxide radical production in human myocardium. Annals of Thoracic Surgery 59:169-172.
    • Clerk A., Bogoyevitch M.A., Fuller S.J., LAZOU A., Parker P. and Sugden P.H. (1995). Expression of protein kinase C isoforms during cardiac ventricular development in rat and man. American Journal of Physiology 269: Η1087-Η1097
    • Bogoyevitch M.A., Glennon P.E., Andersson M.B., Clerk A., LAZOU A., Marshall C.J., Parker P.J. and Sugden P.H. (1994). Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signalling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signalling pathways leading to myocyte hypertrophy. Journal of Biological Chemistry 269: 1110-1119.
    • LAZOU A., Polydoros I. and Beis I. (1994). The effect of anaerobiosis and anhydrobiosis on the extent of glycolytic enzyme binding in Artemia embryos. Journal of Comperative Physiology 164: 306-311.
    • LAZOU A., Fuller S.J., Bogoyevitch M.A., Orfali K.A. and Sugden P.H. (1994). Characterization of the stimulation of phosphoinositide hydrolysis by α1-adrenergic agonists in adult rat heart. American Journal of Physiology 267: H970-Η978.
    • LAZOU A. and Frosinis A. (1994). Kinetic and regulatory properties of pyruvate kinase from Artemia embryos during incubation under aerobic and anoxic conditions. Comparative Biochemistry and Physiology 109B: 325-332.
    • LAZOU A., Bogoyevitch M.A., Clerk A., Fuller S.J., Marshall C.J. and Sugden P.H. (1994). Regulation of the mitogen-activated protein kinase cascade in adult rat heart preparations in vitro. Circulation Research 75: 932-941.
    • LAZOU A. and Beis A. (1993). Lithium induces changes in the plasma membrane protein pattern of early amphibian embryos. Biology of the Cell 77: 265-268
    • Sugden P.H., Bogoyevitch M.A. and LAZOU A. (1993). From hypertension to hypertrophy: molecular and cellular aspects. Current Advances in ACE Inhibition 3. GA MacGregor and PS Sever (eds), Churchill Livingstone, New York, pp 13-22.
    • LAZOU A., Bogoyevitch M.A., Marshall C.J. and Sugden P.H. (1993). Mitogen-activated (MAP) kinase stimulation by phorbol esters and external load in the isolated perfused heart. Biochem. Soc. Trans. 21: 358S.
    • Bogoyevitch M.A., Glennon P.E., Andersson M.B., LAZOU A., Marshall C.J. and Sugden P.H. (1993). Acidic fibroblast growth factor or endothelin-1 stimulate the MAP kinase cascade in cardiac myocytes. Biochem. Soc. Trans. 21: 356S
    • Touraki M. and LAZOU A. (1992). Protective effect of adenosine against a calcium paradox in the isolated frog heart. Canadian Journal of Physiology and Pharmacology 70: 115-120.
    • Beis A., LAZOU A. and Kontogianni E. (1992). Changes in plasma membrane protein composition during early development of the frog Rana ridibunda. Cellular and Molecular Biology 38: 513-523.
    • LAZOU A. (1991). Regulation of phosphofructokinase in the foot muscle of Patella caerulea (L.) during exposure to air. Journal of Experimental Zoology 259: 202-208.
    • Papadopoulos A., Michaelidis B. and LAZOU A. (1990). Tissue specific isoenzymes of D-lactate dehydrogenase from the foot, mantle and hepatopancreas of Patella caerulea (L.). Purification and properties. International Journal of Biochemistry 22: 601-605.
    • Beis A. and LAZOU A. (1990). Removal of artifactual bands associated with the presence of 2-mercaptoethanol in two-dimensional polyacrylamide gel electrophoresis. Analytical Biochemistry 190: 57-59
    • LAZOU A. (1989). Adenylate metabolizing enzymes in invertebrate tissues. Comperative Biochemistry and Physiology 92B: 175-180.
    • LAZOU A., Michaelidis B. and Beis I. (1989). Evidence for glycolytic enzyme binding during anaerobiosis of the foot muscle of Patella caerulea (L.). Journal of Comparative Physiology 158: 771-777.
    • Michaelidis B., LAZOU A. and Beis I. (1989). The possible role of glycolytic enzyme binding in the control of glycolysis in Patella caerulea foot muscle during stimulation. Comperative Biochemistry and Physiology 93B: 247-250.
    • LAZOU A. and Beis I. (1987). Effects of adenosine perfusion on the metabolism and contractile activity of Rana ridibunda heart. Comperative Biochemistry and Physiology 86C: 415-419.
    • LAZOU A., Gaitanaki C., Michaelidis B., Papadopoulos A. and Beis I. (1987). Purification, catalytic and regulatory properties of malate dehydrogenase from the foot of Patella careulea (L.). Comperative Biochemistry and Physiology 88B: 1033-1040
    • LAZOU A. and Beis I. (1986). Studies on the energy metabolism in the isolated, perfused Rana ridibunda heart. Canadian Journal of Zoology 64: 485-489.
    • LAZOU A. and Beis I. (1986). The role of adenosine in the isolated Rana ridibunda heart. Journal of Comperative Physiology 156: 839-844
    • LAZOU A. and Beis I. (1985). Enzymes of adenosine metabolism in Rana ridibunda heart. Purification and some properties of adenosine kinase. Molecular Physiology 8: 131-142.
    • Michaelidis B., LAZOU A. and Beis I. (1985). Purification, catalytic and regulatory properties of pyruvate kinase from the foot of Patella caerulea (L.). Comperative Biochemistry and Physiology 82B: 405-412
    • Sugden P.H. and LAZOU A. (1984). Activities of cathepsins B, D, H and L in rat heart atrial and ventricular muscle. Cardiovascular Research 18: 483-485